[Remote] Staff Bioinformatics Engineer, Clinical Applications

Note: The job is a remote job and is open to candidates in USA. Helix is hiring a Staff Bioinformatics Engineer, Clinical Applications, to turn genomic variant curation prototypes into production systems. The role builds and scales workflows that automate gene and variant curation, integrate evidence, and support clinical use of genomic data.

Responsibilities

• Productionize curation workflows that support both classical and modern AI/ML approaches to variant classification
• Automate evidence integration from sources such as ClinVar, gnomAD, and PubMed
• Collaborate closely with scientists, product, and clinical stakeholders to ensure software solutions meet scientific and product requirements
• Direct AI coding agents to accelerate development of curation pipelines, applying engineering judgment to validate correctness, security, and architectural fit before deployment
• At Senior level, own defined projects end to end, make technical decisions within agreed priorities and architecture, and raise trade-offs that affect broader systems
• At Staff level, independently frame ambiguous problems, set technical direction, and make consequential architecture and prioritisation decisions across the product area

Skills

• Bachelor's degree in Science or related field with 7+ years (Senior) or 9+ years (Staff) of professional software development experience
• Or, a Master's or Ph.D. with 3+ years (Senior) or 5+ years (Staff) of professional software development experience
• Advanced proficiency in production-quality Python, relational databases, and cloud platforms such as AWS
• Experience productionizing and scaling AI/ML software, especially agentic systems built with frameworks such as LangChain or LangGraph
• Experience collaborating with scientists to integrate bioinformatics/NGS tools and databases into production workflows
• Strong judgment evaluating AI-generated code and pipeline logic for correctness, security, and maintainability before it reaches production
• Experience in clinical genomics, such as ACMG guidelines, clinical diagnostics, or Human Phenotype Ontology (HPO) terms
• Experience developing regulated software, such as software as a medical device
• At Staff level, the role may have the opportunity to take on people leadership responsibilities
• Experience mentoring or managing others, or an interest in developing as a people leader, is a plus

Benefits

• Comprehensive Health Insurance with Date of Hire eligibility
• Above average employer paid premium coverage
• 12 weeks Helix Paid Parental Leave option
• 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire
• Comprehensive Well-Being Benefits
• Flexible PTO
• Remote options for many roles
• A home office stipend

Company Overview

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