[Remote] Senior Director, Commercial Operations

Note: The job is a remote job and is open to candidates in USA. Alnylam Pharmaceuticals is hiring a Senior Director, Commercial Operations to build and advance the capabilities, processes, systems, and services that enable commercial performance. The role partners with cross-functional leaders to translate commercial strategy into execution across field operations, incentive compensation, and CRM.

Responsibilities

• Partner with commercial leadership to translate business, brand, and field strategies into integrated operating plans, priorities, capabilities, and execution roadmaps
• Assess current operations, selectively benchmark external practices, and implement scalable solutions that improve effectiveness, efficiency, quality, and speed
• Identify and eliminate low-value, duplicative, or fragmented work; simplify processes and clarify governance, decision rights, and accountability
• Manage operating expenses and cost-center budgets within scope, including forecasting, prioritization, and vendor oversight
• Provide strategic oversight of the enterprise Incentive Compensation program, ensuring plans for eligible commercial field roles align with business strategy, brand priorities, role expectations, market dynamics, and desired field behaviors; guide senior leaders on design choices, tradeoffs, risks, and implications
• Lead Incentive Compensation governance and decision-making, establishing clear standards, decision rights, approval processes, controls, and cross-functional alignment across Sales, Finance, HR, Legal, Compliance, and other key stakeholders
• Oversee the end-to-end delivery of Incentive Compensation, ensuring the IC team, vendors, and partners effectively execute plan design, modeling, goal and quota setting, administration, calculations, payout validation, inquiries, disputes, and exception management with appropriate quality, controls, and service levels
• Set the strategic direction and accountability for the IC capability, monitoring plan effectiveness and business impact, managing vendor performance, driving continuous improvement and automation, building the multi-year capability roadmap, and developing a high-performing team with clear ownership for day-to-day execution
• Lead field operations capabilities, including field-force sizing and deployment, territory design and alignment, customer targeting and segmentation, call planning, resource optimization, field communications, and execution monitoring
• Partner with Sales and other field leadership to identify business challenges and opportunities and deploy tools, processes, and resources that improve customer engagement and field productivity
• Establish a disciplined field communication and sales execution program that supports consistent rollout of priorities, initiatives, tools, and performance expectations
• Maintain connection to the field and customer environment through appropriate field engagement and feedback mechanisms; translate feedback into practical execution improvements
• Partner with IT, AADS, Training, and business stakeholders to define and execute commercial CRM and technology strategy
• Integrate and automate CRM, sales-force automation, incentive compensation, reporting, and field tools to streamline work, strengthen controls, and improve productivity
• Identify and implement technologies and capabilities that improve execution, information flow, deliverable quality, and user experience
• Ensure appropriate governance, quality assurance, adoption, and compliant use of commercial systems, tools, and resources
• Build, develop, and lead an effective, unified team with clear accountabilities, strong capabilities, and a culture of collaboration, candor, inclusion, and continuous improvement
• Serve as a trusted advisor to senior Commercial leaders and as a key contributor to decisions affecting commercial strategy, investment, execution, and organizational readiness
• Collaborate across Sales, Marketing, Market Access, Medical Affairs, Finance, HR, Legal, Compliance, IT, and other functions to deliver integrated outcomes
• Influence without direct authority, resolve competing priorities, and achieve results through teams in a fast-paced, matrixed environment
• Select, manage, and hold external partners accountable for quality, value, service, controls, and delivery

Skills

• Bachelor's degree required
• 10+ years of progressive experience in biopharma commercial operations, sales operations, field effectiveness, incentive compensation, or a related commercial discipline
• 5+ years of people-management experience, with demonstrated success building teams, developing talent, and achieving results through others
• Proven ability to translate strategy into pragmatic, scalable processes, systems, controls, and actions
• Experience leading cross-functional initiatives and managing interdependent deliverables in a matrixed organization
• Excellent executive communication, presentation, interpersonal, influencing, and negotiation skills
• Demonstrated judgment, integrity, learning agility, and ability to perform effectively in a high-growth, fast-paced environment
• Degree in life sciences, business, finance, or a related field

Benefits

• Annual short-term incentive award (e.g., bonus or sales incentive)
• Annual long-term incentive award (e.g., equity)
• Medical, dental, and vision coverage
• Life and disability insurance
• Lifestyle reimbursement program
• Flexible spending and health savings accounts
• 401(k) with a generous company match
• Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks
• Generous family resources and leave

Company Overview

Company H1B Sponsorship